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22-sep-2019 Posts in category Presonus Cracked
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Mutations in the TGFβ type II receptor gene (TβRII) have been linked to both Marfan syndrome (MFS) and bicuspid aortic valve disease (BAVD). Both syndromes are characterized by progressive aortic root dilation. The aim of this study was to investigate the contribution of cyclooxygenase-2 (COX-2) to the process of aortic root dilatation in these disorders. TβRII-deficient (TβRII-/-) mice were crossed with mice deficient in both COX-2 and COX-1 (COX-2/-COX-1-/-). Histomorphometric and immunohistochemical analyses of the aortic root were performed. TβRII-/- mice exhibited a similar dilation of the aortic root when compared with wild-type mice. Compared with the wild-type group, TβRII-/- mice exhibited a significant increase in aortic root area of more than 35% and a significant increase in COX-2 staining of the aortic wall compared with wild-type mice. Furthermore, COX-2/-COX-1-/- mice developed a similar aortic root dilation as TβRII-/- mice. In addition,
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